Brian Rubin, MD, PhD

Brian Rubin, MD, PhD is Professor of Pathology, Vice-Chair of Research within the Robert J. Tomsich Pathology and Laboratory Medicine Institute, and Director of Soft Tissue Pathology at the Cleveland Clinic. He received his PhD in molecular biology and his MD from Cornell University Medical College. He did his residency in Anatomic Pathology at Brigham and Women’s Hospital and received fellowship training in soft tissue pathology, bone pathology, and cancer genetics.

Dr. Rubin has dedicated his career to a better understanding of the diagnosis and classification of soft tissue neoplasms, especially sarcomas, where he is a prominent figure nationally and internationally. He is widely regarded as a thought leader in the field and is a founding member of the International Society of Bone and Soft Tissue Pathology. His laboratory is focused on understanding the pathogenesis of sarcomas with the major aim of developing targeted therapies. Dr. Rubin has published over 200 peer reviewed journal articles and is the author of numerous reviews and book chapters. He was a member of the working group that authored the WHO Classification of Tumours of Bone and Soft Tissue in 2002 and 2013. He is well known for his work on gastrointestinal stromal tumor (GIST) and other cancers such as melanoma that are driven by oncogenically-activated KIT receptor tyrosine kinase. His group also characterized a novel gene fusion in epithelioid hemangioendothelioma (EHE), a sarcoma with endothelial differentiation. This latest development has allowed them to initiate studies of EHE biology with the goal of developing targeted therapies to treat EHE.

Brian Rubin, MD, PhD Professor of Pathology Director, Soft Tissue Pathology
Vice Chair of Research, Robert J. Tomsich Pathology and Laboratory Medicine Institute Departments of Anatomic Pathology and Cancer Biology
Cleveland Clinic, Lerner Research Institute, and Taussig Cancer Center