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Selected lesions of the head and neck

Speaker: Bruce Wenig, MD

* This speaker has been verified as having no relevant conflicts of interest or financial relationships to disclose.

Course Description (3 Credit Hours)

Case based slide seminar

This course includes a selection of challenging diagnostic cases in head and neck pathology. The 14 selected cases cover a variety of topics including common diagnostic case types confronted by oral pathologists in daily practice as well as less common entities potentially posing difficulties in rendering a specific diagnosis and differentiating from other lesion types. The selected cases include nonneoplastic lesions and neoplasms (benign and malignant). Emphasis will be placed on the light microscopic features of each entity and when required the use and utility of adjunct testing including immunohistochemical staining and molecular analysis in the diagnosis and differential diagnosis. Clinical correlation including treatment and prognosis for specific cases will be discussed.

Objectives of course:

• to identify the criteria and understand the clinical relevance of keratinizing epithelial dysplasia of the upper aerodigestive tract;
• to recognize pathologic features of oropharyngeal human papillomavirus (HPV)-related squamous cell carcinoma and its morphologic variants;
• to describe pathways for p16 overexpression and to interpret p16 immunohistochemical staining;
• to recognize the clinical and pathologic features of select salivary gland neoplasms;
• to utilize adjunct studies (e.g., immunohistochemistry, molecular pathology) in the diagnosis and differential diagnosis of select salivary gland neoplasms
• to diagnose neuroendocrine neoplasms of the head and neck;
• to distinguish between benign and malignant mesenchymal neoplasms.

At the end of this course the participant should be able to recognize the criteria to diagnosis and distinguish between benign and malignant lesions of epithelial, mesenchymal and neuroendocrine origin.